Nobuhiro YUKI, MD, PhD is a Research Professor of the Departments of Medicine and Physiology, National University of Singapore. He received his MD from Niigata University, Niigata, Japan and completed his doctoral degree in Tokyo Medical and Dental University, Tokyo, Japan. Since his first encounter with a Guillain-Barré syndrome (GBS) patient in 1989 and having seen the poor outcome, he promised to dedicate his research life in clarifying the pathogenesis and to develop new treatments. He found that molecular mimicry between peripheral-nerve and microbial components is a cause of GBS. He showed that a complement inhibitor, which has been used for patients with disseminated intravascular coagulation other conditions, is effective for an animal model of GBS. Currently, his laboratory is interested in elucidating target molecules for autoantibodies in chronic inflammatory demyelinating polyneuropathy (CIDP) and also the development of new treatments for GBS and CIDP.
Yuki N. Guillain-Barré syndrome and anti-ganglioside antibodies: a clinician-scientist’s journey, Proc Jpn Acad Ser B Phys Biol Sci. 2012